Vitamin B-Complex + Iron Buclizine Hydrochloride

Appebon with Iron Capsule

Prescription Drug

Nutritional supplement in patients with depressed appetite

Thiamine Mononitrate (Vitamin B₁)

Thiamine plays an essential role as a cofactor in key reactions in carbohydrate metabolism. It acts in two types of reactions upon conversion into the coenzyme thiamine pyrophosphate (TPP): oxidative decarboxylation and transketolation. These reactions are vital in carbohydrate metabolism, specifically in the citric acid cycle (Krebs cycle) and the pentose pathway.

Thiamine assists in blood formation and nerve transmission. It is also involved in the conversion of the amino acid tryptophan to the vitamin niacin and the metabolism of the branched-chain amino acids leucine, isoleucine and valine.

Pyridoxine Hydrochloride (Vitamin B₆)

Pyridoxine is converted to its active forms, pyridoxal phosphate (PLP) and pyridoxamine phosphate (PMP). PLP facilitates more than 100 different enzymatic reactions that support protein metabolism, blood synthesis, carbohydrate metabolism, and neurotransmitter synthesis. It helps produce a number of neurotransmitters including serotonin, gamma amino butyric acid (GABA), dopamine, and epinephrine.

Pyridoxine supports the synthesis of white blood cells of the immune system and is crucial for the synthesis of the red blood cells’ hemoglobin rings, which carry oxygen to hemoglobin. Inadequate vitamin B6 disturbs the binding of oxygen to hemoglobin, causing microcytic hypochromic anemia. In this type of anemia, red blood cells are smaller than normal and also lack sufficient hemoglobin to carry oxygen.

Cyanocobalamin (Vitamin B₁₂)

Cyanocobalamin plays a key role in folate metabolism by transferring a methyl group from the folate coenzyme tetrahydrofolic acid (THFA), which is important in many metabolic pathways. Cyanocobalamin is required in the synthesis of myelin, the white sheath of lipoprotein that surrounds many nerve fibers. During cyanocobalamin deficiency, progressive demyelination of nerve fibers occurs, leading to a variety of neurological symptoms.

Cyanocobalamin is involved in biochemical processes essential for DNA synthesis. A cellular deficiency of vitamin B12 can impair DNA synthesis for growth and division of cells. The lack of DNA affects red blood cells which rapidly turn over every 120 days. When red blood cell precursors in the bone marrow are not able to form new DNA, they cannot divide normally to become red blood cells. As these precursor cells continue to synthesize protein and other cell components, they grow into large, fragile, immature cells which displace red blood cells and cause megaloblastic anemia.

Iron (as Ferrous Fumarate)

Iron is essential in the formation of healthy red blood cells. It is a component of two heme proteins: hemoglobin and myoglobin. Hemoglobin in red blood cells transports oxygen in the blood. Myoglobin in muscles facilitates the movement of oxygen in muscle cells. Iron also acts as a cofactor of enzymes involved in energy metabolism. Cytochromes, for example, are heme-containing compounds critical to the electron transport chain. Iron also has immune-enhancing and cognition-enhancing properties.

Orally, one capsule daily. Or, as prescribed by a physician.

CONTRAINDICATIONS

• Hypersensitivity to any ingredient in the product.
• Patients who are pregnant or breastfeeding

WARNINGS AND PRECAUTIONS

May cause drowsiness. Patients should observe caution while driving or performing other tasks requiring alertness.

Buclizine hydrochloride has atropine-like action and should be used with caution in patients with the following conditions:

• Narrow-angle glaucoma
• Prostatic hypertrophy
• Stenosing peptic ulcer
• Pyloroduodenal obstruction
• Bladder neck obstruction or urinary retention
• Increased intraocular pressure
• Hyperthyroidism
• Cardiovascular disease or hypertension

For more information on safety, precaution and other information about this product, please see the Product Insert.

STORAGE CONDITION

Store at temperatures not exceeding 30°C.

Keep this product out of sight and reach of children.

For more information on safety, precaution and other information about this product, please see the Product Insert.